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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are often characterized by their focus on practical aspects of designing a study, including recruitment and consent, adherence and the use of routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and participants from different geographical regions. This type of heterogeneity, that is crucial for a pragmatic trial to be valid and reduce bias in results, is also necessary. However, too much heterogeneity can lead to problems with the design of the trial.

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The purpose of pragmatic trials is to mimic real-life scenarios and to achieve maximum credibility externally. They are usually commissioned by policymakers and practitioners to inform their decisions. They can also be used to assess the cause-effect relationship of an intervention and 무료 프라그마틱 its effects. They should, however, not, be used to replace explanatory studies.

The idea of pragmatism is controversial and there are concerns regarding whether pragmatic trials could replace tests for explanations or if they should serve as a complement to them. Schwartz and Lellouch1 made a distinction between explanatory studies, which prove a physiological hypothesis or clinical hypothesis, and pragmatic trials that aid in the practice and policy decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic study, including recruitment, design, delivery of the intervention, and follow-up.

The number of pragmatic trials is growing. A recent Medline search using the keywords pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs), yielded 34 articles, as shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.